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Clinical trials of several COX-2 selective and nonselective NSAIDs of up to three years duration have shown an increased risk of serious cardiovascularCVthrombotic eventsincluding myocardial infarctionMIand strokewhich can be fatalBased on available datait is unclear that the risk for CV thrombotic events is similar for all NSAIDsThe relative increase in serious CV thrombotic events over baseline conferred by NSAID use appears to be similar in those with and without known CV disease or risk factors for CV diseaseHoweverpatients with known CV disease or risk factors had a higher absolute incidence of excess serious CV thrombotic eventsdue to their increased baseline rateSome observational studies found that this increased risk of serious Prandin online CV thrombotic events began as early as the first weeks of treatmentThe increase in CV thrombotic risk has been observed most consistently at higher doses.

Advise patients to stop Ponstel immediately if they develop any type of rash and contact their healthcare provider as soon as possiblesee WARNINGSSerious Skin Reactions

Do not use any other over-the-counter coldallergyor pain medication without first asking your doctor or pharmacistMany medicines available over the counter contain medicines similar to mefenamic acidsuch as aspirinibuprofenketoprofenor naproxenIf you take certain products together you may accidentally take too much of this type of medicationRead the label of any other medicine you are using to see if it contains aspirinibuprofenketoprofenor naproxen.

This medicine can increase your risk of life-threatening heart or circulation problemsincluding heart attack or strokeDo not use this medicine just before or after having heart bypass surgeryalso called coronary artery bypass graftor CABG

Before having surgerytell your doctor or dentist that you are using this medication.

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if your physician has instructed or directed you to take generic for ponstel medication in a regular schedule and you have missed a dose of this medicine, take it as soon as you remember.

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